Although the respiratory and immune systems are the major targets of Coronavirus Disease 2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently, detailed pathologic examination of kidney damage in critically ill patients with COVID-19 has been lacking. To help define this we analyzed kidney abnormalities in 26 autopsies of patients with COVID-19 by light microscopy, ultrastructural observation and immunostaining. Patients were on average 69 years (19 male and 7 female) with respiratory failure associated with multiple organ dysfunction syndrome as the cause of death. Nine of the 26 showed clinical signs of kidney injury that included increased serum creatinine and/or new-onset proteinuria. By light microscopy, diffuse proximal tubule injury with the loss of brush border, non-isometric vacuolar degeneration, and even frank necrosis was observed. Occasional hemosiderin granules and pigmented casts were identified. There were prominent erythrocyte aggregates obstructing the lumen of capillaries without platelet or fibrinoid material. Evidence of vasculitis, interstitial inflammation or hemorrhage was absent. Electron microscopic examination showed clusters of coronavirus-like particles with distinctive spikes in the tubular epithelium and podocytes. Furthermore, the receptor of SARS-CoV-2, ACE2 was found to be upregulated in patients with COVID-19, and immunostaining with SARS-CoV nucleoprotein antibody was positive in tubules. In addition to the direct virulence of SARS-CoV-2, factors contributing to acute kidney injury included systemic hypoxia, abnormal coagulation, and possible drug or hyperventilation-relevant rhabdomyolysis. Thus, our studies provide direct evidence of the invasion of SARSCoV-2 into kidney tissue. These findings will greatly add to the current understanding of SARS-CoV-2 infection.
chinese female autopsy video
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Interest in Lam's disappearance increased on February 13 when the Los Angeles Police Department released security camera footage of her behaving erratically in a hotel elevator on the day she was last seen alive. The video went viral.[4][5] While an autopsy performed on February 21 was inconclusive in determining the manner of Lam's death,[6] the Los Angeles County Coroner's office subsequently ruled the death an accident with bipolar disorder being a significant contributing factor.[7]
The autopsy report and its conclusions were also questioned based on the incomplete information. For instance, it does not say what the results of the rape kit and fingernail kit were or even if they were processed.[4] It also records subcutaneous pooling of blood in Lam's anal area,[33] which some observers[who?] suggested was a sign of sexual abuse; one pathologist noted it could also have resulted from bloating in the course of the body's decomposition,[4] and her rectum was also prolapsed.[26] The coroner's pathologists were ambivalent about their conclusion that Lam's death was accidental.[4][failed verification]
Although it is not unheard of to have part of your brain missing, either congenitally or from surgery, the woman joins an elite club of just nine people who are known to have lived without their entire cerebellum. A detailed description of how the disorder affects a living adult is almost non-existent, say doctors from the Chinese hospital, because most people with the condition die at a young age and the problem is only discovered on autopsy (Brain, doi.org/vh7).
In China, hospitals are graded, and the Ministry of Health requires that hospitals belonging to the III and II grades must attain autopsy rates of at least 15% and 10%, respectively. In reality, these percentages are not achieved in many hospitals. For example, the number of autopsies conducted between 1990 and 1999 in Hangzhou (population 6 million), was only 102, which translates into an average of only 10 per year. In a span of 10 years, hospitals in Hangzhou have had only between 1 and 3 autopsies, or even less. The number of autopsies conducted is disproportionate to the size and grading of the hospitals in Hangzhou. In addition, many hospitals do not conduct clinicopathological conferences, resulting in problems in the training of new physicians as well as the development of clinical medicine. Here, an analysis of 4140 autopsies in the past 60 years conducted at Zhejiang University School of Medicine in Hangzhou between 1950 and 2009 was carried out to focus attention on the field.
The number of autopsy cases in the 60 years, the gender and age of the autopsied individuals, comparison of the autopsy and clinical diagnoses, and the distribution of autopsy-determined fatal diseases were determined. In the event of a list of possible clinical diagnoses, only the first three were taken into account for statistical purposes. In the event where any one item from clinical diagnosis overlapped with an item from the autopsy-determined diagnosis, the two diagnoses were said to concur, otherwise being taken as misdiagnosis. We summarized and compared our findings with autopsy reports from some of the other major medical centers in China.
According to the disease categorization, the tumor misdiagnosis rate was 60.99%. Among the 4140 cases, 182 involved malignant tumors. Of these, 71 were correctly diagnosed (39.01%), 81 were misdiagnosed (44.51%), and 30 were undiagnosed (16.48%). The five most common locations of undiagnosed or misdiagnosed cancers were the brain (95.00%), endocrine system (92.30%), urogenital system (75.00%), blood (56.36%) and respiratory tract (46.67%) (Table 3). The discordance rate between clinical and autopsy diagnosis is similar to other report.2
Of these, 2785 were male and 1355 female. The largest number of cases occurred between 1960 and 1969. The fewest were recorded between 1990 and 1999(Figure 1A). The Adult and the infant groups are the major part in all cases (Figure 1B).
Any UFO enthusiast knows about the Roswell spaceship accident where an alien was given an autopsy. In 2001, a document surfaced that electrified UFO enthusiasts, who staunchly believe that the footage which shows a humanoid alien after the Roswell crash in 1947 being taken apart by medics was not faked after all.
According the criminal complaint, on June 21, a 55-year-old female coworker of Dr. Ortiz, identified in court documents as M.K., experienced a medical emergency and died immediately after treating herself for dehydration using an IV bag of saline taken from the surgical center. An autopsy report revealed that she died from a lethal dose of bupivacaine, a nerve blocking agent that is rarely abused but is often used during the administration of anesthesia.
The official document in possession of TCHRD tells a different story. It contains the names of Tibetans who died during the March 2008 protest. There were 22 dead Tibetans kept at Xishan mortuary in Lhasa, in addition to four other Tibetans, whose autopsy reports were included in the internal document. The total number of dead according to this document alone is 26. Of them 15 died from gun shot wounds, out of which 11 were confirmed as Tibetan, while the identity of the other 4 remains unknown at the moment. The document contains information not just about dead Tibetans, but also about where and when they had been killed, the places where their bodies were found.
The autopsy reports on the four Tibetans show that one of them had received 17 gun shot wounds while two women were shot 15 times and eight times respectively. Most of the gunshot wounds were found on their hearts, chests and feet. All of these make clear that the Chinese security forces used machine guns while dealing with the peaceful protestors.
The secret document that TCHRD acquired recently also reveals information about the killing of another Tibetan man at about 8 pm on 16 March 2008. The autopsy reports, on which the secret report was based, show that the dead man whose height was 1.7 meters tall was a native of Village No. 2 of Dogde Township near Lhasa, and he died after he was shot on his waist, just above his buttocks, as bullets emerged from the front of his waist. The video that was released by the CTA and the autopsy report on the dead Tibetan from Dogde raise legitimate suspicions that the Chinese security forces used random shootings and disproportionate force.
12. Anonymous, female, nationality and birthplace remain unknown. She was shot on 14 March 2008 at Ching Phin guesthouse near Ramoche Temple. Her body was found the same day near Ching Phin guesthouse, Lhasa.
14. Anonymous, female, nationality and birthplace remain unknown. She was shot on 14 March 2008 at Ching Phin guesthouse near Ramoche temple. Her body was found the same day near Ching Phin guesthouse near Ramoche Temple, Lhasa.
15. Anonymous, female. Information on her birthplace and the exact time she was shot remains unknown. although she was shot on 14 March 2008. Her body was recovered at Goten Hospital for Nuns (?) on 16 March 2008.
The report (092), 2008 is a secret Chinese internal document prepared by criminal and medical examination department of the Public Security Bureau, Lhasa. The Lhasa PSB ordered the autopsy at 10.30 am on 20 March 2008, and it was performed at 12 pm on the same day. And the autopsy was conducted at Xishan mortuary, Lhasa. The identity of the victim on whom the autopsy was conducted remains unknown, but his nationality is Tibetan.
The report (093), 2008 is a secret Chinese internal document prepared by criminal and medical examination department of the Public Security Bureau, Lhasa. The Lhasa PSB ordered the autopsy at 10.30 am on 20 March 2008, and it was performed at 12 pm on the same day. And the autopsy was conducted at Xishan mortuary, Lhasa. The identity of the victim on whom the autopsy was conducted remains unknown, but her nationality is Tibetan.
The report (094) 2008 is a secret Chinese internal document prepared by criminal and medical examination department of the Public Security Bureau, Lhasa. The Lhasa PSB ordered the autopsy at 10.30 am on 20 March 2008, and it was performed at 12 pm on the same day. And the autopsy was conducted at Xishan mortuary, Lhasa. The identity of the victim on whom the autopsy was conducted remains unknown, but the victim is female and Tibetan. 2ff7e9595c
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